There has been some questions regarding the safety and efficacy of integrating spore-based probiotics (Bacillus) typically because many Americans are unfamiliar with them. Bacillus spores are and have been prescribed in europe and have been extensively studied in human clinical trials.
Most often, we are familiar with lactobacillus sp. and bifidobacter sp. because they currently dominate the health industry. However, popularity does not equate to efficacy. When these organisms are supplemented orally they are generally destroyed by stomach acid and bile salts. This is just one of the many major benefits of spores, they survive through the gastric system and colonize the gastrointestinal tract.
On this page I list scientific literature highlighting the use of these supplements. I have included the study, please feel free to read the full studies.
This page will begin with reviews of the research and then each specific species and their documented use. Keep in mind, that much of the research reviews these strains and contain information within that can be perceived in different ways.
Characterisation, Actions, Mechanisms & Safety
Characterization of Bacillus Species Used for Oral Bacteriotherapy and Bacterioprophylaxis of Gastrointestinal Disorders.
Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers.
The spore of Bacillus indicus produces 22 highly bioavailable forms of carotenoids such as astaxanthin, zeaxanthin, beta carotene and lutein at the site of absorption, the digestive tract.
Efficacy of Bacillus clausii spores in the prevention of recurrent respiratory infections in children: a pilot study
Bacillus clausii therapy to reduce side-effects of anti-Helicobacter pylori treatment randomized, double-blind, placebo controlled trial.
Efficacy and Safety of Bacillus clausii in Preventing Antibiotic-associated Diarrhea among Filipino Infants and Children: A Multi-center, Randomized, Open-label Clinical Trial.
Efficacy of Bacillus clausii strain UBBC-07 in the treatment of patients suffering from acute diarrhoea.
Bacillus clausii effect on gene expression pattern in small bowel mucosa using DNA microarray analysis.
Cytokines evaluation in nasal lavage of allergic children after Bacillus clausii administration: A pilot study.
The highly effective biological preparation biosporin
In addition, spores have been shown to:
- Facilitate production and absorption of critical nutrients such as carotenoids, quinols, vitamins, and enzymes.
- Improve digestion of food and thus improved nutrient absorption.
- Detoxification of the intestinal tract.
- Reduce inflammation associated with Crohn's disease, IBS, ulcerative colitis.
- Improve growth of natural flora.